ClinVar Miner

Submissions for variant CYP2C9*3

gnomAD frequency: 0.04900  dbSNP: rs1057910
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Total submissions: 11
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Eurofins Ntd Llc (ga) RCV000339502 SCV000331714 other not provided 2015-07-10 criteria provided, single submitter clinical testing
Medical Genetics Summaries RCV000787930 SCV000926949 drug response Flurbiprofen response 2019-02-11 criteria provided, single submitter curation The dose of flurbiprofen should be reduced in individuals with 2 decreased function alleles (CYP2C9 poor metabolizers) to avoid abnormally high plasma levels due to reduced metabolic clearance.
Medical Genetics Summaries RCV000788094 SCV000927092 drug response Lesinurad response 2019-02-11 criteria provided, single submitter curation Lesinurad should be used with caution in individuals with 2 decreased function alleles (CYP2C9 poor metabolizers) because of increased exposure and an increased risk of side effects.
Medical Genetics Summaries RCV000788100 SCV000927098 drug response Piroxicam response 2019-02-11 criteria provided, single submitter curation Individuals with 2 decreased function alleles (CYP2C9 poor metabolizers) have reduced clearance of piroxicam. Because the standard recommended dose of piroxicam may cause abnormally high plasma levels, a dose reduction should be considered for these individuals.
OMIM RCV000008916 SCV000029126 drug response Tolbutamide response 2010-12-30 no assertion criteria provided literature only
OMIM RCV000008917 SCV000029127 drug response Warfarin response 2012-06-15 no assertion criteria provided literature only
OMIM RCV000008918 SCV000029128 drug response Phenytoin response 2012-06-15 no assertion criteria provided literature only
OMIM RCV000008919 SCV000029129 drug response Glipizide response 2012-06-15 no assertion criteria provided literature only
Pharmacogenomics Lab, Chungbuk National University RCV000008917 SCV000889937 drug response Warfarin response 2010-08-31 no assertion criteria provided research
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne RCV000008918 SCV001441534 drug response Phenytoin response 2020-09-24 no assertion criteria provided case-control May cause toxicity/ADR and poor metabolism/PK
Faculty of Pharmacy, Damascus University RCV000008917 SCV005397927 drug response Warfarin response no assertion criteria provided research rs1057910 is a SNP in the CYP2C9 gene and is linked to poor warfarin metabolism and risk of GI bleeding with warfarin, rs1057910 is associated with reduced enzyme activity and lower clearance rates of warfarin leading to higher rates of warfarin concentration

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