ClinVar Miner

Submissions for variant CYP2C9*3

gnomAD frequency: 0.04900  dbSNP: rs1057910
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Total submissions: 10
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Eurofins Ntd Llc (ga) RCV000339502 SCV000331714 other not provided 2015-07-10 criteria provided, single submitter clinical testing
Medical Genetics Summaries RCV000787930 SCV000926949 drug response Flurbiprofen response 2019-02-11 criteria provided, single submitter curation The dose of flurbiprofen should be reduced in individuals with 2 decreased function alleles (CYP2C9 poor metabolizers) to avoid abnormally high plasma levels due to reduced metabolic clearance.
Medical Genetics Summaries RCV000788094 SCV000927092 drug response Lesinurad response 2019-02-11 criteria provided, single submitter curation Lesinurad should be used with caution in individuals with 2 decreased function alleles (CYP2C9 poor metabolizers) because of increased exposure and an increased risk of side effects.
Medical Genetics Summaries RCV000788100 SCV000927098 drug response Piroxicam response 2019-02-11 criteria provided, single submitter curation Individuals with 2 decreased function alleles (CYP2C9 poor metabolizers) have reduced clearance of piroxicam. Because the standard recommended dose of piroxicam may cause abnormally high plasma levels, a dose reduction should be considered for these individuals.
OMIM RCV000008916 SCV000029126 drug response Tolbutamide response 2010-12-30 no assertion criteria provided literature only
OMIM RCV000008917 SCV000029127 drug response Warfarin response 2012-06-15 no assertion criteria provided literature only
OMIM RCV000008918 SCV000029128 drug response Phenytoin response 2012-06-15 no assertion criteria provided literature only
OMIM RCV000008919 SCV000029129 drug response Glipizide response 2012-06-15 no assertion criteria provided literature only
Pharmacogenomics Lab, Chungbuk National University RCV000008917 SCV000889937 drug response Warfarin response 2010-08-31 no assertion criteria provided research
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne RCV000008918 SCV001441534 drug response Phenytoin response 2020-09-24 no assertion criteria provided case-control May cause toxicity/ADR and poor metabolism/PK

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