Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV004583958 | SCV005065073 | pathogenic | Deficiency of hydroxymethylglutaryl-CoA lyase | 2023-04-18 | criteria provided, single submitter | clinical testing | This variant is a gross deletion of the genomic region encompassing exon(s) 7 of the HMGCL gene. This variant would be expected to be in-frame, preserving the integrity of the reading frame. A similar copy number variant has been observed in individual(s) with HMG-CoA lyase deficiency (PMID: 11129331). For these reasons, this variant has been classified as Pathogenic. This variant disrupts a region of the HMGCL protein in which other variant(s) (p.His233Arg) have been determined to be pathogenic (PMID: 8798725, 9784232, 14518825, 16330550). This suggests that this is a clinically significant region of the protein, and that variants that disrupt it are likely to be disease-causing. Experimental studies have shown that a similar copy number variant affects HMGCL function (PMID: 11129331). Algorithms developed to predict the effect of variants on protein structure and function are not available or were not evaluated for this variant. |