Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Victorian Clinical Genetics Services, |
RCV003225694 | SCV003921982 | pathogenic | Atypical hemolytic-uremic syndrome with I factor anomaly | criteria provided, single submitter | clinical testing | A large heterozygous deletion (approximately 166kb) encompassing CFH exons 10-22 (NM_000186.4), CFHR3 and CFHR1 was detected using whole genome sequencing. While this specific deletion is novel, the smaller deletion of CFHR3 and CFHR1 is a known susceptibility allele for aHUS and has been reported in approximately 26.5% of individuals with aHUS (GeneReviews). Individuals with aHUS harbouring various copy number variants spanning the CFH operon in combination with single nucleotide variants in CFI have been reported (PMIDs: 19861685, 23431077). Microarray analysis confirmed heterozygous deletion of a smaller region (approximately 38.4kb) encompassing CFH exons 10-22 (NM_000186.4). Loss of function variants of CFH are associated with susceptibility to aHUS. Partial deletions of CFH have not been reported. However, complex rearrangements/deletions/gene fusions of the CFH gene family are well documented (Gene Reviews, PMID:20301541, Cantsilieris et al 2018, 29686068) |