ClinVar Miner

Submissions for variant NC_000002.11:g.(?_127821127)_(127834302_?)dup

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000636923 SCV000758369 uncertain significance Myopathy, centronuclear, 2 2018-01-24 criteria provided, single submitter clinical testing This variant is a gross duplication of the genomic region encompassing exons 2-9 of the BIN1 gene. While the exact position of the duplicated exons cannot be determined from this data, sub-genic duplications are generally in tandem (PMID: 25640679). This duplication would be expected to be in-frame, preserving the integrity of the reading frame. This variant has not been reported in the literature in individuals with BIN1-related disease. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Experimental studies and prediction algorithms are not available for this variant, and the functional significance of the duplicated exons is currently unknown.

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