Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV004580126 | SCV005062634 | likely pathogenic | Congenital prothrombin deficiency | 2023-10-18 | criteria provided, single submitter | clinical testing | This variant results in the deletion of exons 7-8 and part of exon 9 (c.560-1081_1090del) of the F2 gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), and loss-of-function variants in F2 are known to be pathogenic (PMID: 23852823). This variant has not been reported in the literature in individuals affected with F2-related conditions. This variant disrupts a region of the F2 protein in which other variant(s) (p.Glu352Lys) have been observed in individuals with F2-related conditions (PMID: 10651742). This suggests that this is a clinically significant region of the protein, and that variants that disrupt it are likely to be disease-causing. In summary, the currently available evidence indicates that the variant is pathogenic, but additional data are needed to prove that conclusively. Therefore, this variant has been classified as Likely Pathogenic. |