Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV003113464 | SCV003793732 | pathogenic | Rubinstein-Taybi syndrome | 2022-04-27 | criteria provided, single submitter | clinical testing | This variant disrupts a region of the CREBBP protein in which other variant(s) (p.Thr1447Ile) have been determined to be pathogenic (PMID: 15706485; Invitae). This suggests that this is a clinically significant region of the protein, and that variants that disrupt it are likely to be disease-causing. This variant has been observed in individual(s) with clinical features of CREBBP-related conditions (Invitae). This variant results in the deletion of exons 26-29 and part of exon 30 (c.4281-274_4927del) of the CREBBP gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), and loss-of-function variants in CREBBP are known to be pathogenic (PMID: 17052327, 18792986). For these reasons, this variant has been classified as Pathogenic. |