ClinVar Miner

Submissions for variant NM_000038.5(APC):c.259C>T (p.Leu87=) (rs569640184)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000163523 SCV000214081 likely benign Hereditary cancer-predisposing syndrome 2015-04-21 criteria provided, single submitter clinical testing
Color RCV000163523 SCV000681538 benign Hereditary cancer-predisposing syndrome 2016-05-28 criteria provided, single submitter clinical testing
GeneDx RCV000433023 SCV000524797 likely benign not specified 2017-09-12 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000122765 SCV000166022 benign Familial adenomatous polyposis 1 2017-11-15 criteria provided, single submitter clinical testing

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