Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV003149087 | SCV003836591 | pathogenic | Familial adenomatous polyposis 1 | 2023-02-19 | reviewed by expert panel | curation | The c.1900dup p.(Ser634Lysfs*17) variant in APC is a frameshift variant located between codon 49 and 2645 and is predicted to cause a premature stop codon in biological-relevant exon 15 in a gene in which loss-of-function is an established disease mechanism (PVS1). This variant has been identified as a de novo occurrence with unconfirmed parental relationships in 1 individual with FAP, the total points scored based on available phenotypic information is 0.5 (PM6_Supporting; PMID 15024739). This variant is absent from gnomAD v2.1.1 (PM2_Supporting). In summary, this variant meets the criteria to be classified as Pathogenic for FAP based on the ACMG/AMP criteria applied, as specified by the ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel: PVS1, PM2_Supporting, PM6_Supporting (VCEP specifications version 1; date of approval: 12/12/2022). |