ClinVar Miner

Submissions for variant NM_000038.6(APC):c.2631T>A (p.Gly877=) (rs762629631)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000163245 SCV000213772 likely benign Hereditary cancer-predisposing syndrome 2016-09-28 criteria provided, single submitter clinical testing
Invitae RCV000228768 SCV000282721 likely benign not provided 2019-01-11 criteria provided, single submitter clinical testing
GeneDx RCV000436441 SCV000516565 likely benign not specified 2018-01-23 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000163245 SCV000681543 likely benign Hereditary cancer-predisposing syndrome 2017-01-25 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000228768 SCV001133314 likely benign not provided 2019-05-31 criteria provided, single submitter clinical testing

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