ClinVar Miner

Submissions for variant NM_000038.6(APC):c.2778T>C (p.Ser926=) (rs371526966)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000220698 SCV000275426 likely benign Hereditary cancer-predisposing syndrome 2015-04-23 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000530592 SCV000600063 benign not provided 2019-03-26 criteria provided, single submitter clinical testing
Invitae RCV001084802 SCV000647267 likely benign Familial adenomatous polyposis 1 2019-12-31 criteria provided, single submitter clinical testing
GeneDx RCV000507103 SCV000728926 likely benign not specified 2017-06-21 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000220698 SCV000904122 likely benign Hereditary cancer-predisposing syndrome 2018-02-05 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000507103 SCV000916508 likely benign not specified 2019-11-25 criteria provided, single submitter clinical testing

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