ClinVar Miner

Submissions for variant NM_000038.6(APC):c.2795C>G (p.Ser932Ter)

dbSNP: rs878853432
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV003335270 SCV002242590 pathogenic Familial adenomatous polyposis 1 2021-12-23 criteria provided, single submitter clinical testing This premature translational stop signal has been observed in individual(s) with familial adenomatous polyposis (PMID: 1338764, 10083733, 20223039, 20685668). This variant is not present in population databases (gnomAD no frequency). This sequence change creates a premature translational stop signal (p.Ser932*) in the APC gene. While this is not anticipated to result in nonsense mediated decay, it is expected to disrupt the last 1912 amino acid(s) of the APC protein. ClinVar contains an entry for this variant (Variation ID: 236581). For these reasons, this variant has been classified as Pathogenic. A different truncation (p.Tyr2645Lysfs*14) that lies downstream of this variant has been determined to be pathogenic (PMID: 9824584, 1316610, 27081525, 8381579, 22135120, Invitae). This suggests that deletion of this region of the APC protein is causative of disease. This variant is expected to disrupt the EB1 and HDLG binding sites, which mediate interactions with the cytoskeleton (PMID: 15311282, 17293347). While functional studies have not been performed to directly test the effect on APC protein function, this suggests that disruption of the C-terminal portion of the protein is functionally important.
Myriad Genetics, Inc. RCV003335270 SCV004045098 pathogenic Familial adenomatous polyposis 1 2023-05-05 criteria provided, single submitter clinical testing This variant is considered pathogenic. This variant creates a termination codon and is predicted to result in premature protein truncation.

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