ClinVar Miner

Submissions for variant NM_000038.6(APC):c.2952A>G (p.Glu984=) (rs772562489)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000423032 SCV000522506 likely benign not specified 2015-12-24 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000543399 SCV000647285 likely benign not provided 2018-12-11 criteria provided, single submitter clinical testing
Ambry Genetics RCV000571501 SCV000675900 likely benign Hereditary cancer-predisposing syndrome 2017-08-01 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Color RCV000571501 SCV000681564 likely benign Hereditary cancer-predisposing syndrome 2017-01-09 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000423032 SCV000918468 likely benign not specified 2019-08-20 criteria provided, single submitter clinical testing

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