ClinVar Miner

Submissions for variant NM_000038.6(APC):c.477C>T (p.Tyr159=) (rs863224281)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000198065 SCV000252924 likely benign Familial adenomatous polyposis 1 2017-11-16 criteria provided, single submitter clinical testing
Counsyl RCV000198065 SCV000488609 likely benign Familial adenomatous polyposis 1 2016-05-10 criteria provided, single submitter clinical testing
GeneDx RCV000438858 SCV000515495 likely benign not specified 2016-09-06 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics RCV000564772 SCV000667391 likely benign Hereditary cancer-predisposing syndrome 2016-01-05 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic RCV000438858 SCV000691705 likely benign not specified no assertion criteria provided clinical testing

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