Submissions for variant NM_000038.6(APC):c.477C>T (p.Tyr159=) (rs863224281)

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Total submissions: 5

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000198065	SCV000252924	likely benign	Familial adenomatous polyposis 1	2017-11-16	criteria provided, single submitter	clinical testing
Counsyl	RCV000198065	SCV000488609	likely benign	Familial adenomatous polyposis 1	2016-05-10	criteria provided, single submitter	clinical testing
GeneDx	RCV000438858	SCV000515495	likely benign	not specified	2016-09-06	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics	RCV000564772	SCV000667391	likely benign	Hereditary cancer-predisposing syndrome	2016-01-05	criteria provided, single submitter	clinical testing	Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic	RCV000438858	SCV000691705	likely benign	not specified		no assertion criteria provided	clinical testing

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