Submissions for variant NM_000038.6(APC):c.5952T>C (p.Asn1984=) (rs142019870)

Minimum review status:		Collection method:
Minimum conflict level:
		ClinVar version:

Total submissions: 5

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000432139	SCV000523758	likely benign	not specified	2016-01-26	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae	RCV000469890	SCV000562598	likely benign	Familial adenomatous polyposis 1	2016-11-08	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000566862	SCV000672555	likely benign	Hereditary cancer-predisposing syndrome	2017-01-06	criteria provided, single submitter	clinical testing	Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Color	RCV000566862	SCV000904169	likely benign	Hereditary cancer-predisposing syndrome	2018-08-07	criteria provided, single submitter	clinical testing
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic	RCV000432139	SCV000691759	likely benign	not specified		no assertion criteria provided	clinical testing

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