ClinVar Miner

Submissions for variant NM_000038.6(APC):c.6135C>T (p.Ser2045=) (rs187297940)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000679075 SCV000166047 likely benign not provided 2019-03-02 criteria provided, single submitter clinical testing
GeneDx RCV000435748 SCV000512081 benign not specified 2015-05-14 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000435748 SCV000591196 likely benign not specified 2015-11-19 criteria provided, single submitter clinical testing
Ambry Genetics RCV000574161 SCV000667295 likely benign Hereditary cancer-predisposing syndrome 2015-04-28 criteria provided, single submitter clinical testing
Color RCV000574161 SCV000681784 likely benign Hereditary cancer-predisposing syndrome 2016-12-06 criteria provided, single submitter clinical testing
PreventionGenetics,PreventionGenetics RCV000679075 SCV000805447 likely benign not provided 2018-01-25 criteria provided, single submitter clinical testing

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