ClinVar Miner

Submissions for variant NM_000038.6(APC):c.6345A>G (p.Leu2115=)

dbSNP: rs1561606585
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Color Diagnostics, LLC DBA Color Health RCV000772211 SCV000905328 likely benign Hereditary cancer-predisposing syndrome 2018-03-16 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV004569432 SCV002427260 likely benign Familial adenomatous polyposis 1 2024-04-30 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV004569432 SCV005083885 benign Familial adenomatous polyposis 1 2024-04-04 criteria provided, single submitter clinical testing This variant is considered benign. This variant is a silent/synonymous amino acid change and it is not expected to impact splicing.

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