ClinVar Miner

Submissions for variant NM_000038.6(APC):c.646-18T>C

gnomAD frequency: 0.00001  dbSNP: rs1434255816
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Color Diagnostics, LLC DBA Color Health RCV000776168 SCV000911252 likely benign Hereditary cancer-predisposing syndrome 2018-06-18 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV003768398 SCV002419878 likely benign Familial adenomatous polyposis 1 2024-10-27 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV003768398 SCV004932072 likely benign Familial adenomatous polyposis 1 2024-02-26 criteria provided, single submitter clinical testing This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.

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