ClinVar Miner

Submissions for variant NM_000038.6(APC):c.7731A>G (p.Ser2577=) (rs537187449)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000216649 SCV000276381 likely benign Hereditary cancer-predisposing syndrome 2016-06-15 criteria provided, single submitter clinical testing
GeneDx RCV000420353 SCV000512088 benign not specified 2015-05-28 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000463756 SCV000562654 likely benign Familial adenomatous polyposis 1 2017-11-17 criteria provided, single submitter clinical testing
Color RCV000216649 SCV000681884 likely benign Hereditary cancer-predisposing syndrome 2016-08-06 criteria provided, single submitter clinical testing
PreventionGenetics,PreventionGenetics RCV000679086 SCV000805471 likely benign not provided 2017-06-12 criteria provided, single submitter clinical testing

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