Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV000532085 | SCV000623277 | uncertain significance | Bloom syndrome | 2023-04-24 | criteria provided, single submitter | clinical testing | Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is not expected to disrupt BLM protein function. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. ClinVar contains an entry for this variant (Variation ID: 454108). This variant has not been reported in the literature in individuals affected with BLM-related conditions. The frequency data for this variant in the population databases is considered unreliable, as metrics indicate poor data quality at this position in the gnomAD database. This sequence change replaces leucine, which is neutral and non-polar, with methionine, which is neutral and non-polar, at codon 842 of the BLM protein (p.Leu842Met). |
Ambry Genetics | RCV001015818 | SCV001176694 | uncertain significance | Hereditary cancer-predisposing syndrome | 2022-08-29 | criteria provided, single submitter | clinical testing | The p.L842M variant (also known as c.2524C>A), located in coding exon 11 of the BLM gene, results from a C to A substitution at nucleotide position 2524. The leucine at codon 842 is replaced by methionine, an amino acid with highly similar properties. This amino acid position is highly conserved in available vertebrate species. In addition, this alteration is predicted to be tolerated by in silico analysis. Since supporting evidence is limited at this time, the clinical significance of this alteration remains unclear. |
Natera, |
RCV000532085 | SCV002088080 | uncertain significance | Bloom syndrome | 2021-04-28 | no assertion criteria provided | clinical testing |