ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.-11C>T (rs76874770)

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Total submissions: 19
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories RCV000755480 SCV000602859 benign not provided 2017-05-24 criteria provided, single submitter clinical testing
Ambry Genetics RCV000131010 SCV000185936 likely benign Hereditary cancer-predisposing syndrome 2013-09-03 criteria provided, single submitter clinical testing
Breast Cancer Information Core (BIC) (BRCA2) RCV000113002 SCV000145987 uncertain significance Breast-ovarian cancer, familial 2 2002-05-29 no assertion criteria provided clinical testing
Color RCV000131010 SCV000683383 benign Hereditary cancer-predisposing syndrome 2015-05-05 criteria provided, single submitter clinical testing
Counsyl RCV000113002 SCV000220306 benign Breast-ovarian cancer, familial 2 2014-05-12 criteria provided, single submitter literature only
DNA and Cytogenetics Diagnostics Unit,Erasmus Medical Center RCV000113002 SCV000744376 benign Breast-ovarian cancer, familial 2 2015-09-21 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000175515 SCV000591651 benign not specified 2014-01-23 criteria provided, single submitter clinical testing
Diagnostic Laboratory, Department of Genetics,University Medical Center Groningen RCV000113002 SCV000733205 benign Breast-ovarian cancer, familial 2 no assertion criteria provided clinical testing
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics RCV000175515 SCV000227007 benign not specified 2014-07-16 criteria provided, single submitter clinical testing
Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) RCV000113002 SCV000244918 benign Breast-ovarian cancer, familial 2 2015-01-12 reviewed by expert panel curation Class 1 not pathogenic based on frequency >1% in an outbred sampleset. Frequency 0.02236 (African), derived from 1000 genomes (2012-04-30).
Genetic Services Laboratory, University of Chicago RCV000175515 SCV000593696 likely benign not specified 2016-03-10 criteria provided, single submitter clinical testing
Genome Diagnostics Laboratory,University Medical Center Utrecht RCV000113002 SCV000743233 benign Breast-ovarian cancer, familial 2 2017-07-28 criteria provided, single submitter clinical testing
Illumina Clinical Services Laboratory,Illumina RCV000370664 SCV000383599 likely benign Fanconi anemia 2016-06-14 criteria provided, single submitter clinical testing
Illumina Clinical Services Laboratory,Illumina RCV000205927 SCV000383600 likely benign Hereditary breast and ovarian cancer syndrome 2016-06-14 criteria provided, single submitter clinical testing
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. RCV000131010 SCV000679705 likely benign Hereditary cancer-predisposing syndrome 2017-07-12 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000205927 SCV000494355 benign Hereditary breast and ovarian cancer syndrome 2014-04-15 criteria provided, single submitter clinical testing
Invitae RCV000205927 SCV000260705 benign Hereditary breast and ovarian cancer syndrome 2015-09-19 criteria provided, single submitter clinical testing
Michigan Medical Genetics Laboratories,University of Michigan RCV000113002 SCV000195943 benign Breast-ovarian cancer, familial 2 2014-11-03 criteria provided, single submitter clinical testing
PreventionGenetics RCV000175515 SCV000805638 benign not specified 2016-11-22 criteria provided, single submitter clinical testing

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