ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.-15A>C (rs138705202)

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Total submissions: 8
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000168528 SCV000210549 benign not specified 2014-07-01 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics RCV000168528 SCV000227005 likely benign not specified 2015-10-13 criteria provided, single submitter clinical testing
Invitae RCV000200285 SCV000252602 benign Hereditary breast and ovarian cancer syndrome 2015-08-25 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000168528 SCV000591650 likely benign not specified 2012-07-19 criteria provided, single submitter clinical testing
Color RCV000579801 SCV000683384 likely benign Hereditary cancer-predisposing syndrome 2015-11-16 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV000755879 SCV000883522 likely benign not provided 2018-06-26 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000031295 SCV000053900 benign Breast-ovarian cancer, familial 2 2009-09-24 no assertion criteria provided clinical testing
Breast Cancer Information Core (BIC) (BRCA2) RCV000031295 SCV000145978 uncertain significance Breast-ovarian cancer, familial 2 2004-02-20 no assertion criteria provided clinical testing

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