ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.10153C>T (p.Arg3385Cys) (rs397507261)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000130138 SCV000184971 likely benign Hereditary cancer-predisposing syndrome 2018-02-08 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: In silico models in agreement (benign),Other data supporting benign classification
Color RCV000130138 SCV000683396 likely benign Hereditary cancer-predisposing syndrome 2015-04-14 criteria provided, single submitter clinical testing
GeneDx RCV000160261 SCV000210699 likely benign not specified 2016-04-19 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000199846 SCV000252991 likely benign Hereditary breast and ovarian cancer syndrome 2017-11-16 criteria provided, single submitter clinical testing
Michigan Medical Genetics Laboratories,University of Michigan RCV000031302 SCV000196034 benign Breast-ovarian cancer, familial 2 2014-11-03 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000031302 SCV000053907 benign Breast-ovarian cancer, familial 2 2009-08-18 no assertion criteria provided clinical testing

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