ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.1762A>G (p.Asn588Asp) (rs398122731)

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Total submissions: 7
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000160207 SCV000210567 likely benign not specified 2017-06-01 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics RCV000163030 SCV000213518 likely benign Hereditary cancer-predisposing syndrome 2017-04-20 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Other data supporting benign classification
Counsyl RCV000077665 SCV000488195 likely benign Breast-ovarian cancer, familial 2 2016-01-22 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000160207 SCV000591764 likely benign not specified 2013-09-26 criteria provided, single submitter clinical testing
Invitae RCV000531905 SCV000635175 likely benign Hereditary breast and ovarian cancer syndrome 2017-11-28 criteria provided, single submitter clinical testing
Color RCV000163030 SCV000683443 likely benign Hereditary cancer-predisposing syndrome 2015-12-14 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000077665 SCV000109468 likely benign Breast-ovarian cancer, familial 2 2012-05-01 no assertion criteria provided clinical testing

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