Submissions for variant NM_000059.3(BRCA2):c.1762A>G (p.Asn588Asp) (rs398122731)

Total submissions: 7

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000160207	SCV000210567	likely benign	not specified	2017-06-01	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics	RCV000163030	SCV000213518	likely benign	Hereditary cancer-predisposing syndrome	2017-04-20	criteria provided, single submitter	clinical testing	Lines of evidence used in support of classification: Other data supporting benign classification
Counsyl	RCV000077665	SCV000488195	likely benign	Breast-ovarian cancer, familial 2	2016-01-22	criteria provided, single submitter	clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System	RCV000160207	SCV000591764	likely benign	not specified	2013-09-26	criteria provided, single submitter	clinical testing
Invitae	RCV000531905	SCV000635175	likely benign	Hereditary breast and ovarian cancer syndrome	2017-11-28	criteria provided, single submitter	clinical testing
Color	RCV000163030	SCV000683443	likely benign	Hereditary cancer-predisposing syndrome	2015-12-14	criteria provided, single submitter	clinical testing
Sharing Clinical Reports Project (SCRP)	RCV000077665	SCV000109468	likely benign	Breast-ovarian cancer, familial 2	2012-05-01	no assertion criteria provided	clinical testing