ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.497A>T (p.His166Leu) (rs876658364)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000219636 SCV000273479 uncertain significance Hereditary cancer-predisposing syndrome 2015-10-01 criteria provided, single submitter clinical testing Insufficient or conflicting evidence;In silico models in agreement (benign)
Invitae RCV000560532 SCV000635418 likely benign Hereditary breast and ovarian cancer syndrome 2019-11-25 criteria provided, single submitter clinical testing
Color RCV000219636 SCV000904824 likely benign Hereditary cancer-predisposing syndrome 2018-02-01 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000238704 SCV000297532 benign Breast-ovarian cancer, familial 2 2011-03-07 no assertion criteria provided clinical testing

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