Submissions for variant NM_000059.3(BRCA2):c.6821G>T (p.Gly2274Val) (rs55712212)

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Total submissions: 13

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Ambry Genetics	RCV000131679	SCV000186715	benign	Hereditary cancer-predisposing syndrome	2014-12-16	criteria provided, single submitter	clinical testing
Breast Cancer Information Core (BIC) (BRCA2)	RCV000077387	SCV000146944	uncertain significance	Breast-ovarian cancer, familial 2	2004-02-20	no assertion criteria provided	clinical testing
Color	RCV000131679	SCV000683816	benign	Hereditary cancer-predisposing syndrome	2015-04-07	criteria provided, single submitter	clinical testing
Counsyl	RCV000077387	SCV000221133	likely benign	Breast-ovarian cancer, familial 2	2015-02-12	criteria provided, single submitter	literature only
Department of Medical Genetics,University Hospital of North Norway	RCV000077387	SCV000301451	likely benign	Breast-ovarian cancer, familial 2	2016-05-01	no assertion criteria provided	clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System	RCV000074551	SCV000592077	uncertain significance	not specified	2014-01-20	criteria provided, single submitter	clinical testing
Foulkes Cancer Genetics LDI, Lady Davis Institute for Medical Research	RCV000735591	SCV000863729	uncertain significance	Breast and/or ovarian cancer	2014-02-24	no assertion criteria provided	clinical testing
GeneDx	RCV000074551	SCV000108636	likely benign	not specified	2017-10-27	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C.	RCV000131679	SCV000679722	likely benign	Hereditary cancer-predisposing syndrome	2017-07-12	criteria provided, single submitter	clinical testing
Invitae	RCV000045064	SCV000073077	benign	Hereditary breast and ovarian cancer syndrome	2017-12-25	criteria provided, single submitter	clinical testing
PreventionGenetics	RCV000074551	SCV000301768	likely benign	not specified		criteria provided, single submitter	clinical testing
Sharing Clinical Reports Project (SCRP)	RCV000077387	SCV000109184	benign	Breast-ovarian cancer, familial 2	2012-05-01	no assertion criteria provided	clinical testing
True Health Diagnostics	RCV000131679	SCV000787943	likely benign	Hereditary cancer-predisposing syndrome	2017-08-09	no assertion criteria provided	clinical testing

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