ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.6821G>T (p.Gly2274Val) (rs55712212)

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Total submissions: 13
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000131679 SCV000186715 benign Hereditary cancer-predisposing syndrome 2014-12-16 criteria provided, single submitter clinical testing
Breast Cancer Information Core (BIC) (BRCA2) RCV000077387 SCV000146944 uncertain significance Breast-ovarian cancer, familial 2 2004-02-20 no assertion criteria provided clinical testing
Color RCV000131679 SCV000683816 benign Hereditary cancer-predisposing syndrome 2015-04-07 criteria provided, single submitter clinical testing
Counsyl RCV000077387 SCV000221133 likely benign Breast-ovarian cancer, familial 2 2015-02-12 criteria provided, single submitter literature only
Department of Medical Genetics,University Hospital of North Norway RCV000077387 SCV000301451 likely benign Breast-ovarian cancer, familial 2 2016-05-01 no assertion criteria provided clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000074551 SCV000592077 uncertain significance not specified 2014-01-20 criteria provided, single submitter clinical testing
Foulkes Cancer Genetics LDI, Lady Davis Institute for Medical Research RCV000735591 SCV000863729 uncertain significance Breast and/or ovarian cancer 2014-02-24 no assertion criteria provided clinical testing
GeneDx RCV000074551 SCV000108636 likely benign not specified 2017-10-27 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. RCV000131679 SCV000679722 likely benign Hereditary cancer-predisposing syndrome 2017-07-12 criteria provided, single submitter clinical testing
Invitae RCV000045064 SCV000073077 benign Hereditary breast and ovarian cancer syndrome 2017-12-25 criteria provided, single submitter clinical testing
PreventionGenetics RCV000074551 SCV000301768 likely benign not specified criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000077387 SCV000109184 benign Breast-ovarian cancer, familial 2 2012-05-01 no assertion criteria provided clinical testing
True Health Diagnostics RCV000131679 SCV000787943 likely benign Hereditary cancer-predisposing syndrome 2017-08-09 no assertion criteria provided clinical testing

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