ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.7435+6G>A (rs81002852)

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Total submissions: 15
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Breast Cancer Information Core (BIC) (BRCA2) RCV000031678 SCV000147083 uncertain significance Breast-ovarian cancer, familial 2 2002-05-29 no assertion criteria provided clinical testing
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario RCV000768633 SCV000219392 benign Breast and/or ovarian cancer 2016-05-25 criteria provided, single submitter clinical testing
Color RCV000210777 SCV000683872 benign Hereditary cancer-predisposing syndrome 2016-01-05 criteria provided, single submitter clinical testing
Counsyl RCV000031678 SCV000220684 likely benign Breast-ovarian cancer, familial 2 2014-09-10 criteria provided, single submitter literature only
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000168598 SCV000592108 benign not specified 2014-08-13 criteria provided, single submitter clinical testing
GeneDx RCV000168598 SCV000167393 benign not specified 2013-10-30 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Genetic Services Laboratory, University of Chicago RCV000168598 SCV000593729 likely benign not specified 2016-08-24 criteria provided, single submitter clinical testing
Hereditary Cancer Genetics group,Vall d'Hebron Institute of Oncology RCV000167780 SCV000916365 benign Hereditary breast and ovarian cancer syndrome 2019-03-01 no assertion criteria provided research
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. RCV000210777 SCV000803156 likely benign Hereditary cancer-predisposing syndrome 2018-05-23 criteria provided, single submitter clinical testing
Invitae RCV000167780 SCV000073224 benign Hereditary breast and ovarian cancer syndrome 2017-12-28 criteria provided, single submitter clinical testing
PreventionGenetics RCV000679187 SCV000805762 likely benign not provided 2016-10-03 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000168598 SCV000600749 benign not specified 2017-06-19 criteria provided, single submitter clinical testing
Research Molecular Genetics Laboratory,Women's College Hospital, University of Toronto RCV000168598 SCV000587893 uncertain significance not specified 2014-12-23 no assertion criteria provided research
Sharing Clinical Reports Project (SCRP) RCV000031678 SCV000054285 benign Breast-ovarian cancer, familial 2 2009-02-03 no assertion criteria provided clinical testing
Vantari Genetics RCV000210777 SCV000267022 uncertain significance Hereditary cancer-predisposing syndrome 2016-02-05 criteria provided, single submitter clinical testing

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