ClinVar Miner

Submissions for variant NM_000059.3(BRCA2):c.7436-10T>C (rs398122582)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000470480 SCV000560476 likely benign Hereditary breast and ovarian cancer syndrome 2017-09-27 criteria provided, single submitter clinical testing
GeneDx RCV000608246 SCV000729203 likely benign not specified 2017-11-28 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Counsyl RCV000076995 SCV000785022 likely benign Breast-ovarian cancer, familial 2 2017-03-23 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000076995 SCV000108792 likely benign Breast-ovarian cancer, familial 2 2011-11-21 no assertion criteria provided clinical testing

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