Submissions for variant NM_000059.4(BRCA2):c.1909+22del

dbSNP: rs276174816

Total submissions: 13

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Labcorp Genetics (formerly Invitae), Labcorp	RCV000043921	SCV000071934	benign	Hereditary breast ovarian cancer syndrome	2024-01-31	criteria provided, single submitter	clinical testing
Counsyl	RCV000119249	SCV000154100	benign	Breast-ovarian cancer, familial, susceptibility to, 2	2014-04-10	criteria provided, single submitter	literature only
Cancer Genetics and Genomics Laboratory, British Columbia Cancer Agency	RCV000496608	SCV000586932	benign	not specified	2017-04-18	criteria provided, single submitter	clinical testing
Department of Pathology and Molecular Medicine, Queen's University	RCV000496608	SCV000588081	uncertain significance	not specified	2017-04-20	criteria provided, single submitter	clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000496608	SCV000602806	benign	not specified	2016-11-12	criteria provided, single submitter	clinical testing
Color Diagnostics, LLC DBA Color Health	RCV000580530	SCV000683457	likely benign	Hereditary cancer-predisposing syndrome	2015-03-11	criteria provided, single submitter	clinical testing
Genome Diagnostics Laboratory, University Medical Center Utrecht	RCV000119249	SCV000743268	benign	Breast-ovarian cancer, familial, susceptibility to, 2	2014-10-09	criteria provided, single submitter	clinical testing
Mendelics	RCV000119249	SCV001139015	benign	Breast-ovarian cancer, familial, susceptibility to, 2	2019-05-28	criteria provided, single submitter	clinical testing
Institute for Clinical Genetics, University Hospital TU Dresden, University Hospital TU Dresden	RCV003237717	SCV002010728	benign	not provided	2021-11-03	criteria provided, single submitter	clinical testing
Sema4, Sema4	RCV000580530	SCV002533275	benign	Hereditary cancer-predisposing syndrome	2020-05-27	criteria provided, single submitter	curation
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital	RCV000496608	SCV002550296	benign	not specified	2023-08-15	criteria provided, single submitter	clinical testing
Breast Cancer Information Core (BIC) (BRCA2)	RCV000119249	SCV000145974	uncertain significance	Breast-ovarian cancer, familial, susceptibility to, 2	1999-04-12	no assertion criteria provided	clinical testing
PreventionGenetics, part of Exact Sciences	RCV004542868	SCV004798217	likely benign	BRCA2-related disorder	2021-03-03	no assertion criteria provided	clinical testing	This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).