ClinVar Miner

Submissions for variant NM_000059.4(BRCA2):c.7618-19G>T

gnomAD frequency: 0.00001  dbSNP: rs371417084
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Michigan Medical Genetics Laboratories, University of Michigan RCV000210995 SCV000196007 uncertain significance Breast-ovarian cancer, familial, susceptibility to, 2 2014-11-03 criteria provided, single submitter clinical testing
GeneDx RCV000605290 SCV000730904 likely benign not specified 2017-11-24 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Mendelics RCV000210995 SCV001139189 benign Breast-ovarian cancer, familial, susceptibility to, 2 2019-05-28 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV001490270 SCV001694831 likely benign Hereditary breast ovarian cancer syndrome 2023-05-19 criteria provided, single submitter clinical testing

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