Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Quest Diagnostics Nichols Institute San Juan Capistrano | RCV003478872 | SCV004220635 | pathogenic | not provided | 2023-08-24 | criteria provided, single submitter | clinical testing | The BRCA2 c.8995_8996del (p.Leu2999Valfs*18) variant alters the translational reading frame of the BRCA2 mRNA and causes the premature termination of BRCA2 protein synthesis. This variant has been reported in the published literature in individuals with breast cancer (PMIDs: 32341426 (2020), 32658311 (2021)). This variant has not been reported in large, multi-ethnic general populations (Genome Aggregation Database, http://gnomad.broadinstitute.org). Based on the available information, this variant is classified as pathogenic. |
Medical Genetics Laboratory, |
RCV001554316 | SCV001774836 | likely pathogenic | Breast carcinoma | 2021-08-08 | no assertion criteria provided | clinical testing | appendix cancer |