Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Department of Immunology and Histocompatibility, |
RCV001090004 | SCV001245414 | pathogenic | Hereditary angioedema type 1 | criteria provided, single submitter | clinical testing | The c.-22-155G > T variant was detected in intron 1 of the SERPING1 gene in two unrelated male C1-INH HAE Type I patients (Vatsiou et al., 2020). Pedigree analysis was performed in one Greek family, in which the c.-22-155G > T variant co-segregated with C1-INH-HAE in all of the 4 analyzed patients, while it was absent from 3 healthy family members. Multiple bioinformatics tools predicted that the variant causes a deleterious effect. Degradation of the mutated allele was demonstrated by the loss of heterozygosity on the cDNA level. It was not detected amongst the 31360 individuals of the Genome Aggregation Database (gnomAD), indicating that it is not a common variant. Taking all the above into account and according to ACMG Guidelines (Criteria: PP1 criterion used as strong evidence, PS3, PS4, PM2, PP3, PP4) the variant is considered pathogenic. |