Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Invitae | RCV000694547 | SCV000822998 | uncertain significance | Beckwith-Wiedemann syndrome | 2018-05-14 | criteria provided, single submitter | clinical testing | This sequence change replaces proline with alanine at codon 158 of the CDKN1C protein (p.Pro158Ala). The proline residue is weakly conserved and there is a small physicochemical difference between proline and alanine. While this variant is not present in population databases, the frequency information is unreliable, as metrics indicate poor data quality at this position in the ExAC database. This variant has been observed in an individual affected with Beckwith–Wiedemann syndrome (PMID: 26077438). Algorithms developed to predict the effect of missense changes on protein structure and function do not agree on the potential impact of this missense change (SIFT: "Deleterious"; PolyPhen-2: "Benign"; Align-GVGD: "Class C0"). In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. |