Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Institute for Genomic Statistics and Bioinformatics, |
RCV001250422 | SCV001424583 | likely pathogenic | Cockayne syndrome type 1 | criteria provided, single submitter | clinical testing | Using trio-exome sequencing and analysis of the genes with the ten highest PEDIA values (PMID: 31164752), a probably pathogenic homozygous missense variant was detected in exon 9 of the ERCCB gene. The name of the variant is: NM_000082: c.797A>C;p.(Asp266Ala) . Both parents carry the variant in heterozygous form. In the population-based database gnomAD this variant is listed once in heterozygous form {allele frequency 0.00000398), in the population-based databases ExAC, 1000Genomes and the Exome Variant Server it is not listed. In the phenotype-related database HGMD the above variant is once listed as pathogenic (PMID : 30111349); in ClinVar and LOVD the variant is not found. In addition, another exchange of the affected amino acid (p.Asp266Gly) has already been published as pathogenic (PMID: 19894250 , 16865293). The mutation prediction programs MutationTaster, SIFT and PolyPhen-2 classify the variant as pathogenic, the CADD score is 27.3. One of the most highly conserved amino acids of the ERCC8 protein, located in a WD protein domain, is affected. The ACMG classification for this variant is: probably pathogenic (Class 4: PM1, PM2, PMS, PP3) |