Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Color Diagnostics, |
RCV001182131 | SCV001347485 | uncertain significance | Familial thoracic aortic aneurysm and aortic dissection | 2023-12-05 | criteria provided, single submitter | clinical testing | Variant of Uncertain Significance due to insufficient evidence: This missense variant replaces phenylalanine with valine at codon 1356 of the COL3A1 protein. Computational prediction tools and conservation analyses suggest that this variant may have deleterious impact on the protein function. Computational splicing tools suggest that this variant may not impact RNA splicing. To our knowledge, functional assays have not been performed for this variant nor has this variant been reported in individuals affected with cardiovascular disorders in the literature. This variant is rare in the general population and has been identified in 0/277264 chromosomes by the Genome Aggregation Database (gnomAD). Available evidence is insufficient to determine the role of this variant in disease conclusively. |
Labcorp Genetics |
RCV001338238 | SCV001531890 | uncertain significance | Ehlers-Danlos syndrome, type 4 | 2020-02-15 | criteria provided, single submitter | clinical testing | In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Experimental studies and prediction algorithms are not available or were not evaluated, and the functional significance of this variant is currently unknown. This variant has not been reported in the literature in individuals with COL3A1-related conditions. This variant is not present in population databases (ExAC no frequency). This sequence change replaces phenylalanine with valine at codon 1356 of the COL3A1 protein (p.Phe1356Val). The phenylalanine residue is highly conserved and there is a small physicochemical difference between phenylalanine and valine. |
Phosphorus, |
RCV001823762 | SCV002073474 | uncertain significance | not specified | 2022-01-18 | criteria provided, single submitter | clinical testing | This missense variant results in a substitution of phenylalanine with valine at codon 1356 of the COL3A1 gene (transcript NM_000090.3). This variant has been reported in ClinVar (922200) NM_000090.4 (COL3A1):c.4066T>G (p.Phe1356Val). The variant has not occurred in population databases. This position is conserved. In silico functional algorithms agree, predicting it as possibly damaging (PolyPhen) and deleterious (SIFT), but no functional studies were performed to confirm these predictions. The variant has not occurred in the literature associated with the disease. In conclusion, the available evidence is insufficient to determine the pathogenicity of this variant. Therefore, it is classified as a Variant of Uncertain Significance. |