Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Gene |
RCV000413679 | SCV000490498 | pathogenic | not provided | 2016-03-02 | criteria provided, single submitter | clinical testing | The p.G2037E pathogenic variant in the COL7A1 gene has been reported previously (Jonkman et al., 1999, Sawamura et al., 2005, 2006, Almaani et al 2011). The p.G2037E variant was not observed in approximately 6500 individuals of European and African American ancestry in the NHLBI Exome Sequencing Project, indicating it is not a common benign variant in these populations. The p.G2037E variant is a non-conservative amino acid substitution, which is likely to impact secondary protein structure as these residues differ in polarity, charge, size and/or other properties. This substitution occurs at a position that is conserved across species. In silico analysis predicts this variant is probably damaging to the protein structure/function as it occurs at the first Glycine position of the canonical Gly-X-Y repeat in the collagenous domain of the colVII protein. Glycine substitution variants in this region of the collagen VII protein will destabilize the collagen triple helix resulting in anchoring fibrils that are fragile and result in poor anchoring off the basement membrane to the underlying dermis. Missense variants in nearby residues (G2034R, E, W, V, G2040S, V, D) have been reported in the Human Gene Mutation Database in association with DEB (Stenson et al., 2014), supporting the functional importance of this region of the protein. We interpret p.G2037E as a pathogenic variant. |
Center for Research in Genodermatoses and Epidermolysis Bullosa, |
RCV000019004 | SCV002499386 | pathogenic | Generalized dominant dystrophic epidermolysis bullosa | 2022-03-14 | criteria provided, single submitter | clinical testing | |
OMIM | RCV000019004 | SCV000039291 | pathogenic | Generalized dominant dystrophic epidermolysis bullosa | 2006-01-01 | no assertion criteria provided | literature only |