ClinVar Miner

Submissions for variant NM_000102.4(CYP17A1):c.644T>G (p.Val215Gly)

dbSNP: rs1428700861
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Medical Cytogenetics and Molecular Genetics Laboratory, IRCCS Istituto Auxologico Italiano RCV001270218 SCV001364349 likely pathogenic Premature ovarian failure 2020-03-02 criteria provided, single submitter research
Women's Health and Genetics/Laboratory Corporation of America, LabCorp RCV003323811 SCV004030004 uncertain significance not specified 2023-07-25 criteria provided, single submitter clinical testing Variant summary: CYP17A1 c.644T>G (p.Val215Gly) results in a non-conservative amino acid change in the encoded protein sequence. Four of five in-silico tools predict a damaging effect of the variant on protein function. The variant allele was found at a frequency of 4e-06 in 251464 control chromosomes (gnomAD). The available data on variant occurrences in the general population are insufficient to allow any conclusion about variant significance. c.644T>G has been reported in the literature in a setting of targeted whole exome sequencing in an individual affected with primary ovarian insufficiency (Bestetti_2021). This report does not provide unequivocal conclusions about association of the variant with Congenital Adrenal Hyperplasia. To our knowledge, no experimental evidence demonstrating an impact on protein function has been reported. The following publication has been ascertained in the context of this evaluation (PMID: 34480478). One submitter has provided a clinical-significance assessment for this variant to ClinVar after 2014 and has classified the variant as likely pathogenic. Based on the evidence outlined above, the variant was classified as uncertain significance.

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