ClinVar Miner

Submissions for variant NM_000106.5(CYP2D6):c.841_843delAAG (p.Lys281del) (rs5030656)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics RCV000734616 SCV000862770 other not provided 2018-08-06 criteria provided, single submitter clinical testing
GeneDx RCV000734616 SCV000977545 likely benign not provided 2018-04-12 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Bruce Budowle Laboratory,University of North Texas Health Science Center RCV001028801 SCV001191587 drug response Tramadol response 2018-04-28 no assertion criteria provided research

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