Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
ARUP Laboratories, |
RCV001802583 | SCV002048958 | likely pathogenic | Hereditary factor VIII deficiency disease | 2021-07-23 | criteria provided, single submitter | clinical testing | The F8 c.1481T>G; p.Ile494Ser variant is reported in the literature in at least one individual affected with moderate to severe hemophilia A (see F8 database and references therein). This variant is absent from the Genome Aggregation Database, indicating it is not a common polymorphism. Additionally, another variant at this codon (c.1481T>C, p.Ile494Thr) has been reported in individuals with mild hemophilia A and is considered pathogenic (Schwaab 1995). The isoleucine at codon 494 is highly conserved, and computational analyses predict that this variant is deleterious (REVEL: 0.983). Based on available information, this variant is considered to be likely pathogenic. References: Link to Factor VIII database: https://f8-db.eahad.org/index.php Johnsen JM et al. Novel approach to genetic analysis and results in 3000 hemophilia patients enrolled in the My Life, Our Future initiative. Blood Adv. 2017 May 18;1(13):824-834. PMID: 29296726. Schwaab R et al. Characterization of mutations within the factor VIII gene of 73 unrelated mild and moderate haemophiliacs. Br J Haematol. 1995 Oct;91(2):458-64. PMID: 8547094. |