Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
ARUP Laboratories, |
RCV003736380 | SCV004563194 | pathogenic | not provided | 2023-07-07 | criteria provided, single submitter | clinical testing | The F8 c.4473C>G; p.Tyr1491Ter variant, also known as Y1492X, as well as another nonsense variant at the same position (c.4473C>A; p.Tyr1491Ter, ClinVar Variation ID: 449368), are reported in the literature in multiple individuals affected with severe hemophilia A (Casana 2008, Green 2008, Johnsen 2017). The c.4473C>G; p.Tyr1491Ter variant is absent from the Genome Aggregation Database, indicating it is not a common polymorphism. This variant induces an early termination codon and is predicted to result in a truncated protein or mRNA subject to nonsense-mediated decay. Based on available information, this variant is considered to be pathogenic. References: Casana P et al. Severe and moderate hemophilia A: identification of 38 new genetic alterations. Haematologica. 2008 Jul;93(7):1091-4. PMID: 18403393. Green PM et al. Haemophilia A mutations in the UK: results of screening one-third of the population. Br J Haematol. 2008 Oct;143(1):115-28. PMID: 18691168. Johnsen JM et al. Novel approach to genetic analysis and results in 3000 hemophilia patients enrolled in the My Life, Our Future initiative. Blood Adv. 2017 May 18;1(13):824-834. PMID: 29296726. |