Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
ARUP Laboratories, |
RCV001802542 | SCV002048817 | likely pathogenic | Hereditary factor VIII deficiency disease | 2020-10-12 | criteria provided, single submitter | clinical testing | The F8 c.55A>C; p.Ser19Arg variant, to our knowledge, is not reported in the literature. However, other DNA changes leading to the same protein change (c.57T>A; p.Ser19Arg and c.57T>G; p.Ser19Arg) have been described in individuals with hemophilia and are considered pathogenic (Lu 2018, Strmecki 1999). The c.55A>C; p.Ser19Arg variant is also absent from general population databases (Exome Variant Server, Genome Aggregation Database), indicating it is not a common polymorphism. The serine at codon 19 is moderately conserved, and computational analyses predict that this variant is deleterious (REVEL: 0.735). Based on available information, this variant is considered to be likely pathogenic. References: Lu Y et al. Spectrum and origin of mutations in sporadic cases of haemophilia A in China. Haemophilia. 2018 Mar;24(2):291-298. Strmecki L et al. Screen of 55 Slovenian haemophilia A patients: identification of 2 novel mutations (S-1R and IVS23+1G-->A) and discussion of mutation spectrum. Mutation in brief no. 241. Online. Hum Mutat. 1999;13(5):413. |