Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
ARUP Laboratories, |
RCV001286176 | SCV001472705 | likely pathogenic | Hereditary factor VIII deficiency disease | 2020-06-11 | criteria provided, single submitter | clinical testing | The F8 c.7021G>A; p.Glu2341Lys variant is reported in the literature in individuals affected with severe hemophilia A (Berber 2006, Gouw 2011, Green 2008). This variant is absent from general population databases (Exome Variant Server, Genome Aggregation Database), indicating it is not a common polymorphism. The glutamic acid at codon 2341 is highly conserved, and computational analyses (SIFT, PolyPhen-2) predict that this variant is deleterious. Based on available information, this variant is considered to be likely pathogenic. References: Berber E et al. DNA microarray analysis for the detection of mutations in hemophilia A. J Thromb Haemost. 2006;4(8):1756-1762. Gouw SC et al. Influence of the type of F8 gene mutation on inhibitor development in a single centre cohort of severe haemophilia A patients. Haemophilia. 2011;17(2):275-281. Green PM et al. Haemophilia A mutations in the UK: results of screening one-third of the population. Br J Haematol. 2008;143(1):115-128. |