Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Gene |
RCV000479958 | SCV000572918 | pathogenic | not provided | 2017-01-31 | criteria provided, single submitter | clinical testing | Although the c.2050_2054dupTGTTG pathogenic variant in the FBN1 gene has not been reported to our knowledge, this variant causes a shift in reading frame starting at codon alanine 686, changing it to a valine, and creating a premature stop codon at position 34 of the new reading frame, denoted p.Ala686ValfsX34. This pathogenic variant is expected to result in either an abnormal, truncated protein product or loss of protein from this allele through nonsense-mediated mRNA decay. Other frameshift variants in the FBN1 gene have been reported in Human Gene Mutation Database in association with FBN1-related disorders (Stenson et al., 2014), indicating that loss of function is a mechanism of disease for this gene. Furthermore, the c.2050_2054dupTGTTG variant has not been observed in large population cohorts (Lek et al., 2016; Exome Variant Server). |