ClinVar Miner

Submissions for variant NM_000138.5(FBN1):c.274G>A (p.Gly92Arg)

dbSNP: rs2140734026
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Centre of Medical Genetics, University of Antwerp RCV002246024 SCV002025278 likely pathogenic Marfan syndrome 2021-03-01 criteria provided, single submitter research PM2, PP3, PS6, PP4
Labcorp Genetics (formerly Invitae), Labcorp RCV002034611 SCV002307869 likely pathogenic Marfan syndrome; Familial thoracic aortic aneurysm and aortic dissection 2021-08-04 criteria provided, single submitter clinical testing This sequence change replaces glycine with arginine at codon 92 of the FBN1 protein (p.Gly92Arg). The glycine residue is highly conserved and there is a moderate physicochemical difference between glycine and arginine. In summary, the currently available evidence indicates that the variant is pathogenic, but additional data are needed to prove that conclusively. Therefore, this variant has been classified as Likely Pathogenic. This variant disrupts the p.Gly92 amino acid residue in FBN1. Other variant(s) that disrupt this residue have been observed in individuals with FBN1-related conditions (PMID: 31730815), which suggests that this may be a clinically significant amino acid residue. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may create or strengthen a splice site, but this prediction has not been confirmed by published transcriptional studies. Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt FBN1 protein function. This variant has been observed in individual(s) with clinical features of Marfan syndrome (PMID: 25907466, Invitae). This variant is not present in population databases (ExAC no frequency).

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