ClinVar Miner

Submissions for variant NM_000138.5(FBN1):c.347-2A>C

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
All of Us Research Program, National Institutes of Health RCV004015829 SCV004839101 likely pathogenic Marfan syndrome 2024-01-08 criteria provided, single submitter clinical testing This variant causes a A to C nucleotide substitution at the -2 position of intron 4 of the FBN1 gene. Splice site prediction tools predict that this variant may have a significant impact on RNA splicing. Although this prediction has not been confirmed in published RNA studies, this variant is expected to result in an absent or disrupted protein product. This variant has not been reported in individuals affected with FBN1-related disorders in the literature. This variant has not been identified in the general population by the Genome Aggregation Database (gnomAD). A different variant occurring at the same position, c.347-2A>G, has been reported in individuals affected with Marfan syndrome and is known to be disease-causing (ClinVar variation ID: 519716). Loss of FBN1 gene function is a known mechanism of disease (clinicalgenome.org). Based on the available evidence, this variant is classified as Likely Pathogenic.

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