ClinVar Miner

Submissions for variant NM_000152.5(GAA):c.1426C>A (p.Leu476Met)

dbSNP: rs756613882
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000810435 SCV000950634 uncertain significance Glycogen storage disease, type II 2022-10-05 criteria provided, single submitter clinical testing In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) has been performed at Invitae for this missense variant, however the output from this modeling did not meet the statistical confidence thresholds required to predict the impact of this variant on GAA protein function. ClinVar contains an entry for this variant (Variation ID: 654467). This missense change has been observed in individual(s) with Pompe disease (PMID: 22676651). This variant is not present in population databases (gnomAD no frequency). This sequence change replaces leucine, which is neutral and non-polar, with methionine, which is neutral and non-polar, at codon 476 of the GAA protein (p.Leu476Met).

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