Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV002009938 | SCV002279196 | likely pathogenic | Glycogen storage disease, type IV; Glycogen storage disease IV, classic hepatic | 2020-12-31 | criteria provided, single submitter | clinical testing | In summary, the currently available evidence indicates that the variant is pathogenic, but additional data are needed to prove that conclusively. Therefore, this variant has been classified as Likely Pathogenic. This variant disrupts a region of the protein in which other variant(s) (p.Tyr686His, p.Ile694Asn) have been observed in individuals with GBE1-related conditions (Invitae). This suggests that this may be a clinically significant region of the GBE1 protein. Nucleotide substitutions within the consensus splice site are a relatively common cause of aberrant splicing (PMID: 17576681, 9536098). Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may disrupt the consensus splice site, but this prediction has not been confirmed by published transcriptional studies. Disruption of this splice site has been observed in individual(s) with glycogen storage disease or polyglucosan body disease (PMID: 27546458, 26789422). This variant is not present in population databases (ExAC no frequency). This sequence change affects a donor splice site in intron 15 of the GBE1 gene. While this variant is not anticipated to result in nonsense mediated decay, it likely alters RNA splicing and results in a disrupted protein product. |
Baylor Genetics | RCV003471239 | SCV004198735 | pathogenic | Glycogen storage disease, type IV | 2022-11-16 | criteria provided, single submitter | clinical testing |