ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.1407T>C (p.Tyr469=) (rs587781408)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000219475 SCV000277003 likely benign Hereditary cancer-predisposing syndrome 2015-06-30 criteria provided, single submitter clinical testing
GeneDx RCV000439040 SCV000515847 likely benign not specified 2017-02-01 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000470875 SCV000561434 likely benign Hereditary nonpolyposis colon cancer 2017-05-27 criteria provided, single submitter clinical testing

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