Submissions for variant NM_000179.2(MSH6):c.1407T>C (p.Tyr469=) (rs587781408)

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Total submissions: 4

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Ambry Genetics	RCV000219475	SCV000277003	likely benign	Hereditary cancer-predisposing syndrome	2015-06-30	criteria provided, single submitter	clinical testing
GeneDx	RCV000439040	SCV000515847	likely benign	not specified	2017-02-01	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae	RCV000470875	SCV000561434	likely benign	Hereditary nonpolyposis colorectal neoplasms	2019-12-31	criteria provided, single submitter	clinical testing
Color	RCV000219475	SCV001358553	likely benign	Hereditary cancer-predisposing syndrome	2018-12-04	criteria provided, single submitter	clinical testing

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