ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.1560T>C (p.Gly520=) (rs762396230)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000167452 SCV000218308 likely benign Hereditary cancer-predisposing syndrome 2014-12-31 criteria provided, single submitter clinical testing
Counsyl RCV000412265 SCV000488833 likely benign Hereditary nonpolyposis colorectal cancer type 5 2016-06-27 criteria provided, single submitter clinical testing
GeneDx RCV000436719 SCV000513683 likely benign not specified 2017-12-19 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000473073 SCV000561437 likely benign Hereditary nonpolyposis colon cancer 2017-11-17 criteria provided, single submitter clinical testing
Color RCV000167452 SCV000906505 likely benign Hereditary cancer-predisposing syndrome 2016-04-26 criteria provided, single submitter clinical testing

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