ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.1668T>C (p.Tyr556=) (rs730882130)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000164263 SCV000214888 likely benign Hereditary cancer-predisposing syndrome 2014-11-10 criteria provided, single submitter clinical testing
Color RCV000164263 SCV000685211 likely benign Hereditary cancer-predisposing syndrome 2016-11-14 criteria provided, single submitter clinical testing
GeneDx RCV000426588 SCV000527324 likely benign not specified 2016-12-22 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Illumina Clinical Services Laboratory,Illumina RCV000161937 SCV000430963 uncertain significance Lynch syndrome 2016-06-14 criteria provided, single submitter clinical testing
Invitae RCV000627737 SCV000211922 likely benign Hereditary nonpolyposis colon cancer 2017-10-14 criteria provided, single submitter clinical testing

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