ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.1752T>G (p.Thr584=) (rs1114167777)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000491160 SCV000580334 likely benign Hereditary cancer-predisposing syndrome 2016-05-13 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign,In silico models in agreement (benign)
Invitae RCV000630373 SCV000751329 likely benign Hereditary nonpolyposis colon cancer 2017-12-13 criteria provided, single submitter clinical testing

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